NEW YORK (Reuters Health) - Use of isotretinoin, the active ingredient in the acne drug Accutane, apparently more than doubles the risk of depression, according to results of a study. The study is the first controlled investigation to find a statistically significant link between isotretinoin and depression, Dr. Nonetheless, "current guidelines should possibly be modified to include psychiatric assessments of patients prior to and during isotretinoin therapy. Based on previous research, the researchers focused on isotretinoin use in the 5 months prior to depression diagnosis (risk period) compared with a 5-month period a year before the diagnosis (control period). Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters. read more
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